Clinical Trials

Created date:February 15th, 2018


Acute lymphoblastic leukemia

Phase I/II clinical trial of remission induction therapy with nelarabine, fludarabine, and etoposide for refractory T-cell acute lymphoblastic leukemia in children (ALL-RT11)

JCCG—ALL committee/Tadashi Kumamoto

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

Phase II multi-center clinical trials of T-cell acute lymphoblastic leukemia in children and young adults (ALL-T11)

JCCG-ALL committee/Arata Watanabe

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

Phase II/III multi-center clinical trial of B-cell precursor acute lymphoblastic leukemia in children(ALL-B12)

JCCG-ALL committee /Katsuyoshi Koh

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

International study for treatment of standard-risk childhood relapsed ALL 2010 (IntReALL SR 2010)

JCCG-relapsed ALL committee/Hidemi Toyoda

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

Prospective observatory study of childhood acute lymphoblastic leukemia with recurrence or induction failure(ALL-R14)

JCCG-relapsed ALL committee /Hiroaki Goto

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

Prospective observatory study of childhood acute lymphoblastic leukemia with recurrence or induction failure(ALL-R14)

JCCG-relapsed ALL committee /Hiroaki Goto

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm


Acute myelogenous leukemia/chronic myelogenous leukemia

Phase II/III multi-center randomized clinical trial to assess better administration schedules of cytarabine in remission induction therapy of children with AML, combined with assessment of the impact of minimal residual disease at early point after remission induction therapy (AML-12)

JCCG-AML committee/Soichi Adachi and Daisuke Tomizawa

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

Phase II multi-center clinical trial of acute promyelocytic leukemia in children. (AML-P13)

JCCG-AML committee /Hiroyuki Takahashi

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

Clinical trial of stoppage of tyrosine kinase inhibitors in children with CML achieving molecular remission(STKI-14)

JCCG-CML committee /Hiroyuki Shimada

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm


Malignant lymphoma

Phase IIb multi-center clinical trial of childhood lymphoblastic lymphoma stage Ⅰ/Ⅱ(LLB-NHL03)

JCCG-Lymphoma committee/Katsuhiko Sunami

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

Phase II multi-center clinical trial to assess effectiveness and safety of DexICE therapy in relapsed and refractory lymphoblastic lymphoma Stage Ⅲ/Ⅳ in children(ALB-R13)

JCCG-Lymphoma committee/Tetsuo Mitsui

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

Multi-center collaborative study to assess prognostic factors of advanced stage lymphoblastic lymphoma in children receiving standard chemotherapy(ALB-NHL-14)

JCCG-Lymphoma committee/Takeshi Mori

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

Phase II clinical trial to assess effective evaluation of initial treatment response in treatment for pediatric Hodgkin lymphoma(HL-14)

JCCG-Lymphoma committee /Yuki Koga

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

Multi-center collaborative study to assess effectiveness and safety of LMB-chemotherapy including rituximab for high-risk mature B-cell lymphoma in children(B-NHL-14)

JCCG-Lymphoma committee /Tetsuya Mori

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm


Other hematological disorders

Phase II clinical trial of hematological stem cell transplantation combined with conditioning using intravenous Bu + Flu + L-PAM for juvenile myelomonocytic leukemia (JMML)(JMML-11)

JCCG-JMML committee/Atsushi Manabe

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

Clinical trial of pediatric Langerhans cell histiocytosis with various risks(LCH-12)

JCCG-HLH/LCH committee/Akira Morimoto

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

Clinical trial of pediatric Langerhans cell histiocytosis with various risks(LCH-12)

JCCG-HLH/LCH committee/Akira Morimoto

URL:http://jplsg.jp/menu6_contents/index_menu_6_siken.htm

A prospective multi-center randomized study to compare dosages of rabbit anti-thymocyte globulin in patients with severe aplastic anemia.

Japan Childhood Aplastic Anemia Study Group/Seiji Kojima


Solid tumors

Phase II multi-center clinical trial of pediatric liver tumor without any remote metastasis at onset, including a new risk classification(JPLT3-S, I)

JCCG-Liver tumor committee/Eiso Hiyama

URL:http://home.hiroshima-u.ac.jp/eiso/oshirase.html

A multi-center collaborative study to assess the safety of dose-dense cisplatin combined with surgery for high-risk hepatoblastoma. (JPLT3-H)

JCCG-Liver tumor committee/Eiso Hiyama

URL:http://home.hiroshima-u.ac.jp/eiso/oshirase.html

Phase II clinical trial of delayed approach to the primary site in high-risk neuroblastoma

JCCG-Neuroblastoma committee /Hideo Mugishima

URL:http://www.jnbsg.jp/

A pilot study of intravenous and intrathecal chemotherapy combined with delayed radiation therapy for atypical teratoid/rhabdoid tumor

JCCG-Brain tumor committee/Junichi Hara

A pilot study of multi-modal treatment with a newly-developed risk classification for medulloblastoma

JCCG-Brain tumor committee/Junichi Hara

Evaluation of kidney preservation in patients with bilateral renal tumor treated with unified protocol in Japan(RTBL14)

JCCG-Renal tumor committee/Masahiro Fukuzawa

URL:http://jwits.umin.ac.jp/


Epidemiological studies and others

Epidemiological study of idiopathic thrombocytopenic purpura in children

JSPHO Platelet committee/ Masue Imaizumi

URL:http://www.jspho.jp/old/disease_committee/itp.html

Observatory study of pediatric solid tumors

Japan pediatric solid tumor clinical trial consortium・Japanese society of pathology-pediatric tumor committee /Junichi Hara, Jyunichiro Fujimoto

Retrospective study of non-Hodgkin lymphoma among patients with hereditary disorders

JCCG-Lymphoma committee/Tomoo Osumi

URL:http://jplsg.jp/menu6_contents/hojikinnrinnpa.pdf

Survey of rare leukemia

JSPHO-Leukemia/lymphoma committee/Yasushi Ishida

URL:http://www.jspho.jp/old/disease_committee/leukemia_lymphoma.html